miRNA and tropism of human parvovirus B19

miRNA and tropism of human parvovirus B19

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpr...

Human parvovirus B19 and pediatric rheumatologic disease

Purpose Human Parvovirus B19 causes a self-limited febrile illness with a characteristic exanthem and occasional acute arthritis. B19 infection has also been associated with multiple rheumatic diseases. Reports indicate that in patients with positive B19 PCR up to ~1/3 have negative IgM and positive IgG to B19. However little is known about how these findings might relate to rheumatologic sympt...

Henoch-Schönlein purpura and human parvovirus B19.

Parvovirus B19.

N Engl J Med 2004;350:586-97. Copyright © 2004 Massachusetts Medical Society. vonne cossart, an australian virologist working in london in the mid-1970s, noted an anomalous reaction of a normal blood donor’s serum (occupying position 19 in plate B) in an assay for hepatitis B. When Cossart excised the line of antigen–antibody precipitation, she saw the particles shown in Figure 1A, and in this ...

The structure of human parvovirus B19.

Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3.5-A resolution by x-ray crystallography and, to our knowledge, represents the first near-atomic structure of an Erythrovirus. The polypeptide fold of the major capsid protein VP2 is a "jelly roll" with a beta-barrel motif similar to tha...